ART eOne: A Compact Automated Magnetic-Bead Platform for Rapid and Flexible DNA/RNA Extraction in Molecular Research Workflows

A scalable 1–16 sample nucleic acid extraction system designed to combine rapid processing, workflow flexibility, and cost-efficient laboratory automation Abstract Efficient and reproducible nucleic acid extraction is a critical upstream step in molecular biology, genomics, infectious disease research, oncology research, and other nucleic acid–based applications. Conventional extraction workflows may require laboratories to choose between manual processing, which can be labor-intensive, and higher-throughput automated platforms that may be inefficient when only a small number of samples require processing. ART eOne, developed by ART BIOTECH, LLC, is a compact benchtop automated DNA/RNA extraction system designed to address this workflow gap. Using magnetic bead–based nucleic acid purification, ART eOne provides flexible processing of 1 to 16 samples per run, allowing laboratories to process either a single specimen or a complete 16-sample plate according to workload. The system is designed for an approximate 12-minute processing time, a 100 µL elution volume, integrated UV decontamination, and touchscreen-controlled operation. When used with the ART DNA/RNA Extraction Kit, the platform provides an integrated approach to nucleic acid purification across a broad range of research sample types. With a stated processing cost of approximately $3.00 per sample, ART eOne is designed to provide laboratories with a practical balance of automation, throughput flexibility, reagent utilization, and operating efficiency. Keywords: ART eOne, automated DNA extraction, automated RNA extraction, nucleic acid extraction, DNA RNA purification, magnetic bead extraction, nucleic acid purification system, molecular biology laboratory automation, DNA extraction instrument, RNA extraction instrument, magnetic bead nucleic acid purification, molecular research, ART BIOTECH The Growing Need for Flexible Nucleic Acid Extraction Automation DNA and RNA extraction is one of the most important pre-analytical steps in molecular research. Regardless of the downstream technology—qPCR, RT-qPCR, sequencing, genotyping, gene-expression analysis, or other molecular methods—the quality and consistency of extracted nucleic acid can directly affect downstream analytical performance.As molecular laboratories expand their research capabilities, extraction workflows increasingly need to satisfy several requirements simultaneously: speed, reproducibility, ease of operation, contamination control, flexible throughput, and economical reagent use.High-throughput instruments can be highly effective for laboratories processing large batches continuously. However, many laboratories experience variable workloads. A laboratory may need to process 16 specimens during one run but only one, two, or several specimens during the next.ART eOne was designed around this practical laboratory challenge. From 1 Sample to 16: Automation That Adapts to the Laboratory A defining feature of ART eOne is its flexible 1–16 sample processing capability. The system is designed to process a single sample when needed, or up to 16 samples in a complete run.This flexibility can be particularly valuable for research laboratories with fluctuating specimen volumes, laboratories developing new molecular assays, and facilities that want automation without requiring large batch sizes for every extraction.Instead of structuring the laboratory workflow around the extraction instrument, ART eOne is designed to allow the extraction workflow to adapt to the laboratory. Magnetic Bead–Based DNA/RNA Extraction ART eOne utilizes magnetic bead–based nucleic acid extraction, a widely adopted approach for automated DNA and RNA purification.In a typical magnetic-bead workflow, nucleic acids are captured onto appropriately formulated magnetic particles under defined chemical conditions. Magnetic separation facilitates retention of the nucleic-acid-bound particles while unwanted sample components are removed through subsequent washing steps. Purified nucleic acid is then released into an elution solution for downstream molecular applications.Automation of these processes can reduce repetitive manual handling and help standardize extraction steps across samples. ART eOne combines this established purification principle with compact benchtop automation. Approximately 12-Minute Processing for Faster Molecular Workflows Extraction can become a significant bottleneck between sample preparation and downstream molecular analysis. ART eOne is designed for a processing time of approximately 12 minutes per extraction run, enabling laboratories to move rapidly from prepared specimens toward purified nucleic acid.A shorter extraction workflow can be particularly useful when laboratories are performing time-sensitive research, assay-development studies, workflow optimization, or multiple molecular runs during the same working day. Designed for Diverse Research Sample Types ART eOne is designed to support nucleic acid extraction from a broad range of research specimen types, including blood, plasma, serum, swabs, urine, saliva, tissue, cells, and other compatible research sample matrices.This versatility allows a single extraction platform to support multiple molecular research programs. Potential research applications include infectious disease research, oncology research, genetic and molecular research, microbiome and metagenomics, pharmacogenomics, forensic research, and veterinary and agricultural research. Integrated ART DNA/RNA Extraction Kit ART BIOTECH also provides the ART DNA/RNA Extraction Kit, designed for compatibility with ART eOne and other appropriate open extraction systems. The kit uses magnetic bead–based purification chemistry and is designed to provide high nucleic acid yield and purity, consistent extraction performance, non-toxic reagents, ready-to-use reagents, and open-system compatibility.Together, ART eOne and the ART DNA/RNA Extraction Kit provide laboratories with an integrated instrument-and-reagent solution for automated nucleic acid purification. 100 µL Elution Volume for Downstream Molecular Applications ART eOne uses a 100 µL elution volume, providing purified nucleic acid suitable for compatible downstream molecular research workflows.Extracted DNA or RNA may subsequently be evaluated in applications such as qPCR and RT-qPCR, gene-expression research, genotyping, molecular assay development, sequencing workflows, infectious disease research, oncology research, microbiome research, and other nucleic acid–based laboratory applications.The suitability of extracted material for a specific downstream assay should, as with any extraction system, be established during laboratory workflow verification or assay development. Built-In UV Decontamination and Closed-System Design Contamination control is an important consideration in molecular laboratories, particularly where amplified nucleic acids or high-copy-number targets are routinely handled.ART eOne incorporates built-in UV decontamination and a closed extraction configuration designed to support contamination-conscious laboratory practices. These engineering features complement established molecular laboratory procedures for maintaining clean extraction environments and minimizing contamination risk. Intuitive 7-Inch Touchscreen Operation ART eOne incorporates a 7-inch color touchscreen with an intuitive software interface designed for straightforward instrument operation. The user-friendly interface can help laboratories implement automated extraction while reducing the operational complexity associated with larger automation platforms.Its compact benchtop configuration also makes ART eOne suitable for laboratories where workspace is valuable. Small Footprint. Significant Capability. With approximate dimensions of 330 × 420 × 445 mm (W × D × H), ART eOne provides automated nucleic acid extraction within a relatively compact laboratory footprint.This makes the platform particularly attractive for laboratories that want to introduce extraction automation but may not have space for large floor-standing or high-throughput systems. At approximately 28 kg, ART eOne is designed as a dedicated benchtop molecular laboratory instrument. Approximately $3.00 Per Sample: Designed With Laboratory Economics in Mind The economics of molecular workflows extend beyond the purchase price of an instrument. Laboratories must also consider reagents, plastics, consumables, technician time, throughput efficiency, and waste associated with partially utilized batch configurations.When used within the specified ART BIOTECH workflow, ART eOne sample processing is estimated at approximately $3.00 per sample.*Combined with the ability to process only the number of samples required—from 1 to 16—this approach is designed to help laboratories better align reagent and consumable utilization with actual workload.*Processing cost may vary depending on workflow configuration, reagent consumption, consumables, purchasing volume, and laboratory-specific operating conditions. ART eOne at a Glance Feature: ART eOneTechnology: Magnetic bead–based nucleic acid extractionThroughput: 1–16 samples per runProcessing Time: Approximately 12 minutesElution Volume: 100 µLUser Interface: 7-inch color touchscreenUV Decontamination: Built-inDimensions: Approx. 330 × 420 × 445 mmWeight: Approx. 28 kgPower: 110–240 V, 50/60 HzProcessing Cost: Approximately $3.00/sample*Primary Use: Automated DNA/RNA extraction for molecular research workflows Why ART eOne? Modern molecular laboratories do not always operate at a constant sample volume. The ability to move efficiently between low-volume and higher-volume workflows can therefore be as important as maximum throughput itself.Speed. Flexibility. Simplicity. Consistency. Cost efficiency.By combining magnetic bead–based purification, 1–16 sample scalability, approximately 12-minute processing, integrated UV decontamination, touchscreen operation, and a compact benchtop design, ART eOne offers laboratories an alternative to both labor-intensive manual extraction and larger automation platforms that may not be optimized for variable sample volumes.ART eOne — Maximum Performance. Minimum Footprint. Explore ART eOne for Your Molecular Research Laboratory Whether your laboratory is establishing a new molecular workflow, expanding qPCR or RT-qPCR research capabilities, developing molecular assays, or seeking a more flexible approach to automated DNA/RNA extraction, ART eOne is designed to provide scalable nucleic acid purification without unnecessary workflow complexity. For laboratories, research organizations, distributors, and OEM partners interested in ART eOne, extraction reagents, pricing, or product demonstrations, contact: ART BIOTECH, LLCDallas–Farmers Branch, Texas, USAWebsite: www.artbio-tech.comEmail: artbiotech@artbio-tech.comPhone: +1 (817) 908-8371 For Research Use Only (RUO). Not for use in diagnostic procedures.